<div id="readability-page-1"><div><p>Looking today at week-over-week shares outstanding changes among the universe of ETFs covered at ETF Channel, one standout is the SPDR S&amp;P Biotech ETF (Symbol: XBI) where we have detected an approximate $291.0 million dollar outflow -- that's a 3.4% decrease week over week (from 63,900,000 to 61,725,000).  Among the largest underlying components of XBI, in trading today Apellis Pharmaceuticals Inc (Symbol: APLS) is trading flat, Travere Therapeutics Inc (Symbol: TVTX) is off about 2.7%, and Revolution Medicines Inc (Symbol: RVMD) is up by about 0.7%. For a complete list of holdings, visit the XBI Holdings page »   The chart below shows the one year price performance of XBI, versus its 200 day moving average:</p><p> <img src="https://imageproxy.pbkrs.com/https://secure.tickertech.com/pics/2026/40102141841.gif?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="450" height="300" original-src="https://imageproxy.pbkrs.com/https://secure.tickertech.com/pics/2026/40102141841.gif"/> </p><p>  Looking at the chart above, XBI's low point in its 52 week range is $75.68 per share, with $139.19 as the 52 week high point — that compares with a last trade of $135.87.  Comparing the most recent share price to the 200 day moving average can also be a useful technical analysis technique -- learn more about the 200 day moving average ».   </p><hr/><p><b>Free Report: Top 8%+ Dividends (paid monthly)</b> <i></i></p><p>  Exchange traded funds (ETFs) trade just like stocks, but instead of ''shares'' investors are actually buying and selling ''units''.  These ''units'' can be traded back and forth just like stocks, but can also be created or destroyed to accommodate investor demand.  Each week we monitor the week-over-week change in shares outstanding data, to keep a lookout for those ETFs experiencing notable inflows (many new units created) or outflows (many old units destroyed).  Creation of new units will mean the underlying holdings of the ETF need to be purchased, while destruction of units involves selling underlying holdings, so large flows can also impact the individual components held within ETFs.  </p><p> <img height="16" src="https://imageproxy.pbkrs.com/https://www.dividendchannel.com/nslideshow.gif?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="16" original-src="https://imageproxy.pbkrs.com/https://www.dividendchannel.com/nslideshow.gif"/> Click here to find out which 9 other ETFs experienced notable outflows » </p> <h5>Also see:</h5><p>   Barry Rosenstein Stock Picks<br/>   NCP Videos<br/>   George Soros Stock Picks</p><p>The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.</p> </div></div>

APLS

RVMD

TVTX

<p>The SPDR S&P Biotech ETF (XBI) has experienced a significant outflow of approximately $291 million, marking a 3.4% decrease in shares outstanding from 63.9 million to 61.7 million. Key components include Apellis Pharmaceuticals (APLS) trading flat, Travere Therapeutics (TVTX) down 2.7%, and Revolution Medicines (RVMD) up 0.7%. XBI's 52-week range is $75.68 to $139.19, with the last trade at $135.87. This outflow may impact the underlying holdings of the ETF as units are destroyed to accommodate investor demand.</p>

XBI, APLS, TVTX, RVMD: ETF Outflow Alert