<div id="readability-page-1"><div> <h2>Key Points</h2><ul><li>Sales volumes of its multi-cancer early detection test, Galleri, continue to grow strongly. </li><li>The company continues to work toward FDA approval of Galleri, and detailed trial results are expected soon. </li><li>There is no guarantee that Grail will have good news at the ASCO meeting, and investors should be aware of the risks involved in buying the stock. </li><li>10 stocks we like better than Grail ›</li></ul>Grail (NASDAQ: GRAL) shares rose 14% this week as the market warmed to the company's first-quarter earnings report and commentary ahead of its presentation at the American Society of Clinical Oncology (ASCO) meeting. <h2>Grail's difficult 2026</h2>Despite the recent rise, the stock is down almost 28% this year, largely due to the disappointing results from its 3-year trial with England's National Health Service (NHS) involving a 142,000 demographic. The trial's primary endpoint was a statistically significant reduction in late-stage cancers (Stages III and IV) among patients who used Galleri, its multi-cancer early detection (MCED) test.Will AI create the world's first trillionaire? Our team just released a report on the one little-known company, called an &#34;Indispensable Monopoly&#34; providing the critical technology Nvidia and Intel both need. Continue »Unfortunately, the primary endpoint wasn't observed, and the stock crashed in February. The market is worried that the trial results may mean Grail won't receive Food and Drug Administration (FDA) approval, and even if it does, there's the question of insurers' willingness to cover Galleri.<h2>Why the stock is on the comeback trail</h2>With the negatives out of the way, it's important to understand that the aim of the trial was to detect cancers early (Stages I and II), thereby reducing the detection of late-stage cancers compared to the control group. The good news is the trial resulted in a &#34;Substantial increase in the absolute number of Stage I-II cancers in the 12 pre-specified deadly cancer types that are typically found in late stages were observed in the intervention arm,&#34; according to the release details in February. The bad news is &#34;there was a higher than anticipated incidence of Stage III cancers.&#34;As such, management is extending the trial's follow-up period by 6-12 months , and it's possible that, sadly, cancers might develop in the control group, which will prove out Galleri. <img src="https://imageproxy.pbkrs.com/https://g.foolcdn.com/image//query-dXJsPWh0dHBzOi8vZy5mb29sY2RuLmNvbS9lZGl0b3JpYWwvaW1hZ2VzLzg2OTM5Ni9pbnZlc3RpbmctaW4tc3RvY2tzLmpwZyZ3PTcwMA?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="700" height="438" original-src="https://imageproxy.pbkrs.com/https://g.foolcdn.com/image//query-dXJsPWh0dHBzOi8vZy5mb29sY2RuLmNvbS9lZGl0b3JpYWwvaW1hZ2VzLzg2OTM5Ni9pbnZlc3RpbmctaW4tc3RvY2tzLmpwZyZ3PTcwMA"/>Image source: Getty Images. <h2>What changed this week </h2>While there's no guarantee this will happen, the recent results demonstrate that customers remain positive about Galleri, with test volume beating expectations and growing by 50% year-over-year, leading to overall company revenue growth of 28% in the first quarter. Moreover, the company continues to seek FDA approval for Galleri and will present detailed trial results at the ASCO meeting in late May. The data presented could be pivotal in garnering market acceptance. Something for investors to look out for. <h2>Should you buy stock in Grail right now?</h2> Before you buy stock in Grail, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Grail wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you’d have $471,827!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you’d have $1,319,291!* Now, it’s worth noting Stock Advisor’s total average return is 986% — a market-crushing outperformance compared to 207% for the S&amp;P 500. Don't miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors. See the 10 stocks » *Stock Advisor returns as of May 10, 2026. Lee Samaha has no position in any of the stocks mentioned. The Motley Fool recommends Grail. The Motley Fool has a disclosure policy. The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc. </div></div>

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Grail (NASDAQ: GRAL) shares rose 14% this week following positive first-quarter earnings and anticipation of upcoming trial results at the ASCO meeting. Despite this rise, the stock is down nearly 28% this year due to disappointing trial results from a 3-year study with the NHS. Sales volumes for its multi-cancer early detection test, Galleri, are growing, and the company is pursuing FDA approval. However, investors should remain cautious about potential risks and uncertainties surrounding the stock's future performance.

Here's Why Grail Shares Popped Higher This Week